DD-03-171 ( —— )

Catalog No. M16954 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DD-03-171
Note

Research use only, not for human use.
Brief Description

DD-03-171 is a small molecule, CGI1746-based BTK degrader (PROTAC, biochemical IC50=5.1 nM) that efficiently degrade C481S-BTK.
Description

DD-03-171 is a small molecule, CGI1746-based BTK degrader (PROTAC, biochemical IC50=5.1 nM) that efficiently degrade C481S-BTK, exhibits enhanced anti-proliferative effects on mantle cell lymphoma (MCL) cells in vitro by degrading BTK, IKFZ1 and IKFZ3; also displays efficacy against patient-derived xenografts in vivo.
Synonyms

——
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

——
Indication

——

CAS Number

--
Formula Weight

991.16
Molecular Formula

C55H62N10O8
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NC1=CC=CC(C(N=C2NC3=CC=C(C(N4CCN(CCCCCCNC(CNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O)CC4)=O)C=C3)=CN(C)C2=O)=C1C)C8=CC=C(C(C)(C)C)C=C8
Chemical Name

4-(tert-butyl)-N-(3-(6-((4-(4-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)hexyl)piperazine-1-carbonyl)phenyl)amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)benzamide

1. Dobrovolsky D, et al. Blood. 2018 Dec 13. pii: blood-2018-07-862953. doi: 10.1182/blood-2018-07-862953.

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