
BI-0252
CAS No. 1818291-27-8
BI-0252( BI 0252 | BI0252 )
Catalog No. M12794 CAS No. 1818291-27-8
A potent, highly selective, orally active MDM2-p53 interaction inhibitor with IC50 of 4 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 1053 | Get Quote |
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50MG | 2142 | Get Quote |
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100MG | 2790 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameBI-0252
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, highly selective, orally active MDM2-p53 interaction inhibitor with IC50 of 4 nM.
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DescriptionA potent, highly selective, orally active MDM2-p53 interaction inhibitor with IC50 of 4 nM; shows in vivo efficacy in a SJSA-1 xenograft model.
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In Vitro——
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In VivoBI-0252 (orally; 25 mg/kg/day for 13 days and 100 mg/kg for 24 h) leads to time-dependent mRNA induction of TP53 target genes including CDKN1a, MDM2, and BBC3. BI-0252 (iv and po; an iv dose of 5 mg/kg and a po dose of 50 mg/kg) showes low clearance in vivo after iv administration and high clearance after po administration. BI-0252 has high po in vivo exposure and good cellular potency. Animal Model:Nude mice bearing established subcutaneous SJSA-1 tumors Dosage:25 mg/kg/day or a single dose of 100 mg/kg Administration:Orally; 25 mg/kg/day for 13 days and 100 mg/kg for 24 hours Result:Leaded to time-dependent mRNA induction of TP53 target genes. Animal Model:Nontumor-bearing female NMRI nude mice Dosage:An iv dose of 5 mg/kg and a po dose of 50 mg/kg Administration:Iv and po Result:Showed low clearance in vivo after iv administration and high clearance after po administration.
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SynonymsBI 0252 | BI0252
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number1818291-27-8
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Formula Weight566.45
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Molecular FormulaC30H26Cl2FN3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESClC1=CC(NC([C@]23[C@@H](C4=CC=CC(Cl)=C4F)[C@H](C[C@@H](C5=CC=C(C(O)=O)C=C5)C6)[C@H]6N3CC7CC7)=O)=C2C=C1
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Chemical Name4-[(3S,3'S,3'aS,5'R,6'aS)-6-chloro-3'-(3-chloro-2-fluorophenyl)-1'-(cyclopropylmethyl)-2-oxo-1,2,3',3'a,4',5',6',6'a-octahydro-1'H-spiro[indole-3,2'-pyrrolo[3,2-b]pyrrole]-5'-yl]benzoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gollner A, et al. J Med Chem. 2016 Nov 23;59(22):10147-10162.
molnova catalog



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