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YH239-EE

CAS No. 1364488-67-4

YH239-EE( YH 239-EE | YH 239 EE )

Catalog No. M11502 CAS No. 1364488-67-4

YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    YH239-EE
  • Note
    Research use only, not for human use.
  • Brief Description
    YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM.
  • Description
    YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4; induces apoptosis in AML cells and patient samples, induces p53 and activates the apoptotic caspase 3/7 in MOLM-13 (wt-p53) cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    YH 239-EE | YH 239 EE
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    p53/MDM2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1364488-67-4
  • Formula Weight
    504.4056
  • Molecular Formula
    C25H27Cl2N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 55 mg/mL
  • SMILES
    O=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC
  • Chemical Name
    1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Huang Y, et al. ACS Chem Biol. 2014 Mar 21;9(3):802-11.
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