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Pifithrin-β
CAS No. 60477-34-1
Pifithrin-β( Cyclic Pifithrin-α | PFT-β )
Catalog No. M15261 CAS No. 60477-34-1
A cyclic analog of Pifithrin-α and a small molecule inhibitor of p53.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePifithrin-β
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NoteResearch use only, not for human use.
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Brief DescriptionA cyclic analog of Pifithrin-α and a small molecule inhibitor of p53.
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DescriptionA cyclic analog of Pifithrin-α and a small molecule inhibitor of p53; prevents dexamethasone-induced cell death in murine thymocytes with EC50 of 2.01 uM, sensitizes p53-deficient tumors to radiotherapy and chemotherapy and increases apoptosis in cancer cells.
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In VitroPifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β (PFT β), the N-acetyl derivative. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects.
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In Vivo——
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SynonymsCyclic Pifithrin-α | PFT-β
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number60477-34-1
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Formula Weight268.3766
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Molecular FormulaC16H16N2S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2
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Chemical NameImidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pietrancosta N, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1561-4.
2. Barchéchath SD, et al. J Med Chem. 2005 Oct 6;48(20):6409-22.
3. Zuco V, et al. Neoplasia. 2008 Jun;10(6):587-96.
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