Pifithrin-β

Research use only, not for human use.

A cyclic analog of Pifithrin-α and a small molecule inhibitor of p53.

A cyclic analog of Pifithrin-α and a small molecule inhibitor of p53; prevents dexamethasone-induced cell death in murine thymocytes with EC50 of 2.01 uM, sensitizes p53-deficient tumors to radiotherapy and chemotherapy and increases apoptosis in cancer cells.

Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β (PFT β), the N-acetyl derivative. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects.

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Cyclic Pifithrin-α | PFT-β

Apoptosis

MDM2-p53

MDM2-p53

Cancer

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60477-34-1

268.3766

C16H16N2S

>98% (HPLC)

10 mM in DMSO

CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2

Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-

(-20℃)

With Ice Pack

≥ 2 years