Alirocumab

CAS No. 1245916-14-6

Alirocumab( —— )

Catalog No. M22147 CAS No. 1245916-14-6

Alirocumab is a human monoclonal antibody that inhibits PCSK9. It is produced by recombinant DNA technology in Chinese hamster ovary cell suspension culture.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Alirocumab
  • Note
    Research use only, not for human use.
  • Brief Description
    Alirocumab is a human monoclonal antibody that inhibits PCSK9. It is produced by recombinant DNA technology in Chinese hamster ovary cell suspension culture.
  • Description
    Alirocumab is a human monoclonal antibody that inhibits PCSK9. It is produced by recombinant DNA technology in Chinese hamster ovary cell suspension culture.
  • In Vitro
    Cell Viability Assay Cell Line:hiPSC-CMs, hESC-CMs Concentration:0.01, 0.1, 1, 2, 10 μM Incubation Time: 24-72 h Result:Exhibited normal cell viability and did not affect the level of LDH release.
  • In Vivo
    Animal Model:CETP mice model Dosage:3 or 10 mg/kg Administration:s.c.Result:Decreased total cholesterol dose-dependently.Increased hepatic LDL receptor protein levels but did not affect hepatic cholesterol and TG content.Decreased atherosclerotic lesion size and improved plaque morphology.Animal Model:Rat model (240-280 g) Dosage:10 mg/kg Administration:i.p.Result:Elevated ammonia, total cholesterol, LDL and ox-LDL levels.Decreased plasma levels of total cholesterol, LDL, and oxidative stress markers.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    PCSK9
  • Recptor
    PCSK9
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1245916-14-6
  • Formula Weight
    146 kDa
  • Molecular Formula
    ——
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ramanathan A, et al. Alirocumab, a Therapeutic Human Antibody to PCSK9, Does Not Affect CD81 Levels or Hepatitis C Virus Entry and Replication into Hepatocytes. PLoS One. 2016 Apr 26;11(4):e0154498.
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  • Alirocumab

    Alirocumab is a human monoclonal antibody that inhibits PCSK9. It is produced by recombinant DNA technology in Chinese hamster ovary cell suspension culture.