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O-304

CAS No. 1261289-04-6

O-304( O304 )

Catalog No. M11082 CAS No. 1261289-04-6

O-304 is a small molecule AMPK activator and PCSK9 modulator, reduces extracellular and secreted PCSK9 levels in human liver cells and reduces PCSK9 plasma levels and total cholesterol levels in obese rats.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 132 In Stock
10MG 205 In Stock
25MG 410 In Stock
50MG 605 In Stock
100MG 860 In Stock
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Biological Information

  • Product Name
    O-304
  • Note
    Research use only, not for human use.
  • Brief Description
    O-304 is a small molecule AMPK activator and PCSK9 modulator, reduces extracellular and secreted PCSK9 levels in human liver cells and reduces PCSK9 plasma levels and total cholesterol levels in obese rats.
  • Description
    O-304 is a small molecule AMPK activator and PCSK9 modulator, reduces extracellular and secreted PCSK9 levels in human liver cells and reduces PCSK9 plasma levels and total cholesterol levels in obese rats.Diabetes Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    O304
  • Pathway
    Others
  • Target
    PCSK9
  • Recptor
    PCSK9
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    1261289-04-6
  • Formula Weight
    380.243
  • Molecular Formula
    C16H11Cl2N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 30 mg/mL 78.90 mM
  • SMILES
    C1=CC(=CC=C1CN2C(=O)N=C(S2)NC(=O)C3=CC=C(C=C3)Cl)Cl
  • Chemical Name
    4-chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3.
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