
PF-06815345
CAS No. 1900686-46-5
PF-06815345( PF 6815345 )
Catalog No. M12982 CAS No. 1900686-46-5
PF-06815345 (PF 6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 1593 | Get Quote |
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50MG | 3222 | Get Quote |
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100MG | 4410 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NamePF-06815345
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NoteResearch use only, not for human use.
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Brief DescriptionPF-06815345 (PF 6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay.
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DescriptionPF-06815345 (PF 6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay; PF-06815345is identified after optimization of the prodrug moiety to maximize intestinal stability achieving liver targeting of the active compound after prodrug turnover by carboxylesterase (CES1). Hypercholesterolemia Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsPF 6815345
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PathwayOthers
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TargetPCSK9
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RecptorPCSK9
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Research AreaCardiovascular Disease
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IndicationHypercholesterolemia
Chemical Information
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CAS Number1900686-46-5
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Formula Weight598.036
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Molecular FormulaC27H29ClFN9O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O[C@H](N1N=NN=C1C2=C(C3=CC=C(C(N(C4=NC=CC=C4Cl)[C@H]5CNCCC5)=O)C=C3F)C=NN2C)C)OCC
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Chemical Name(S)-1-(5-(4-(4-((3-chloropyridin-2-yl)((R)-piperidin-3-yl)carbamoyl)-2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)-1H-tetrazol-1-yl)ethyl ethyl carbonate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. McClure KF, et al. Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16218-16222.
2. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3.
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