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AQ-101
CAS No. 1353384-61-8
AQ-101( AQ101 )
Catalog No. M11437 CAS No. 1353384-61-8
AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAQ-101
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NoteResearch use only, not for human use.
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Brief DescriptionAQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism.
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DescriptionAQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53; induces apoptosis of acute lymphoblastic leukemia (ALL) especially those with a wild-type p53 phenotype and MDM2 expression in vitro and in vivo; inhibits development of ALL in nude or SCID mice with a human ALL xenograft.
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In Vitro——
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In Vivo——
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SynonymsAQ101
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research Area——
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Indication——
Chemical Information
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CAS Number1353384-61-8
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Formula Weight331.708
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Molecular FormulaC16H10ClNO5
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC(C=C1C2=O)=CC(O)=C1C(C3=C2C=CC=C3O)=O)CCl
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Chemical Name2-chloro-N-(4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gu L, et al. Mol Cancer Ther. 2018 Feb;17(2):497-507.
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