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ISA27
CAS No. 1254366-73-8
ISA27( ISA 27 )
Catalog No. M11032 CAS No. 1254366-73-8
ISA27 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameISA27
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NoteResearch use only, not for human use.
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Brief DescriptionISA27 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.
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DescriptionISA27 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo; reduces cell proliferation and induces apoptosis in vitro in cells carrying either p53 WT or mutated gene, suggesting that its effect is independent from p53 transcriptional activity; induces cancer cell death in a dose-dependent manner through the activation of the mitochondrial-dependent death signalling in p53-mutated cells.
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In Vitro——
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In Vivo——
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SynonymsISA 27
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research Area——
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Indication——
Chemical Information
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CAS Number1254366-73-8
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Formula Weight399.849
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Molecular FormulaC19H14ClN3O3S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(3R,7aR)-6-(4-chlorobenzyl)-1H-spiro[imidazo[1,5-c]thiazole-3,3'-indoline]-2',5,7(6H,7aH)-trione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sorriento D, et al. Br J Cancer. 2015 Jan 6;112(1):77-85.
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