Cart
sales@molnova.com
ISA27
CAS No. 1254366-73-8
ISA27( ISA 27 )
Catalog No. M11032 CAS No. 1254366-73-8
ISA27 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameISA27
-
NoteResearch use only, not for human use.
-
Brief DescriptionISA27 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.
-
DescriptionISA27 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo; reduces cell proliferation and induces apoptosis in vitro in cells carrying either p53 WT or mutated gene, suggesting that its effect is independent from p53 transcriptional activity; induces cancer cell death in a dose-dependent manner through the activation of the mitochondrial-dependent death signalling in p53-mutated cells.
-
In Vitro——
-
In Vivo——
-
SynonymsISA 27
-
PathwayApoptosis
-
TargetMDM2-p53
-
RecptorMDM2-p53
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1254366-73-8
-
Formula Weight399.849
-
Molecular FormulaC19H14ClN3O3S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name(3R,7aR)-6-(4-chlorobenzyl)-1H-spiro[imidazo[1,5-c]thiazole-3,3'-indoline]-2',5,7(6H,7aH)-trione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Sorriento D, et al. Br J Cancer. 2015 Jan 6;112(1):77-85.
molnova catalog
related products
-
RO-2468
A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM.
-
Pifithrin-β
A cyclic analog of Pifithrin-α and a small molecule inhibitor of p53.
-
RETRA hydrochloride
RETRA hydrochloride is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.
