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MB710

CAS No. 2230044-57-0

MB710( MB-710 )

Catalog No. M13571 CAS No. 2230044-57-0

MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    MB710
  • Note
    Research use only, not for human use.
  • Brief Description
    MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro.
  • Description
    MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro.
  • In Vitro
    Cell Viability Assay Cell Line:NUGC3 (mutant p53 Y220C), HUH-7 (mutant p53 Y220C), NUGC4 (p53 WT), HUH-6 cells (p53 WT)Concentration:0-200 μM Incubation Time:72 hours Result:Showed relatively low toxicity against all cell lines tested at concentrations up to 60?μM. NUGC3 was the most sensitive cell line.
  • In Vivo
    ——
  • Synonyms
    MB-710
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    MDM2-p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2230044-57-0
  • Formula Weight
    457.286
  • Molecular Formula
    C16H16IN3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 16.67 mg/mL (36.45 mM)
  • SMILES
    O=C(C1=C2N=C(N(CC)CC)SC2=C(N3C=CC=C3)C(I)=C1O)O
  • Chemical Name
    2-(diethylamino)-5-hydroxy-6-iodo-7-(1H-pyrrol-1-yl)benzo[d]thiazole-4-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Baud MGJ, et al. Eur J Med Chem. 2018 May 25;152:101-114.
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  • MB710

    MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro.

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