MIND-4 ( MIND4;MIND 4 )

Catalog No. M12482 CAS No. 1639965-26-6

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Product Name

MIND-4
Note

Research use only, not for human use.
Brief Description

MIND-4 is a novel potent, selective, non-competitive SIRT2 deacetylase inhibitor.
Description

MIND-4 is a novel potent, selective, non-competitive SIRT2 deacetylase inhibitor with IC50 of 1.2 uM, Ki of 2.1 uM, and also is an inducer of the NRF2 pathway; upregulates the acetylation of nuclear H3 histone substrates lysine-56 and -27 in wild-type primary cortical neurons (DIV11) without effect on lysine-14 of H3 histone, induces transcriptional activation of the NRF2 pathway in HD and wild-type neuronal cells; significantly protects against mHTTex1-induced neurodegeneration in HD models.
Synonyms

MIND4;MIND 4
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

Sirtuin
Research Area

——
Indication

——

CAS Number

1639965-26-6
Formula Weight

455.49
Molecular Formula

C24H17N5O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=[N+](C1=C2C=CC=NC2=C(SC3=NN=C(COC4=CC=CC=C4)N3C5=CC=CC=C5)C=C1)[O-]
Chemical Name

5-nitro-8-((5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)quinoline

1. Quinti L, et al. Cell Chem Biol. 2016 Jul 21;23(7):849-61.

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