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Home - Products - Chromatin/Epigenetic - Sirtuin - YK-3-237

YK-3-237

CAS No. 1215281-19-8

YK-3-237 ( YK-3 237 )

Catalog No. M10805 CAS No. 1215281-19-8

A novel small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    YK-3-237
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53.
  • Description
    A novel small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53; demonstrates proliferation inhibition in breast cancer cell panel with EC50 of 0.1-5 uM, also induces PARP-dependent apoptotic cell death and arrests the cell cycle at G2/M phase; enhances expression of α-SMA and fibronectin in cultured rat renal interstitial fibroblasts (NRK-49F).
  • Synonyms
    YK-3 237
  • Pathway
    Chromatin/Epigenetic
  • Target
    Sirtuin
  • Recptor
    Sirtuin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1215281-19-8
  • Formula Weight
    372.18
  • Molecular Formula
    C19H21BO7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    B(C1=C(C=CC(=C1)C=CC(=O)C2=CC(=C(C(=C2)OC)OC)OC)OC)(O)O
  • Chemical Name
    B-[2-methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]-boronic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yi YW, et al. Oncotarget. 2013 Jul;4(7):984-94.
2. Ponnusamy M, et al. J Pharmacol Exp Ther. 2015 Aug;354(2):142-51.
3. Kong Y, et al. Bioorg Med Chem. 2010 Jan 15;18(2):971-7.
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