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AB-423
CAS No. 1572510-80-5
AB-423 ( AB423;AB423 )
Catalog No. M12247 CAS No. 1572510-80-5
AB-423 is a novel potent, class II HBV capsid inhibitor that shows potent inhibition of HBV replication with EC50 of 0.08-0.27 uM, with no significant cytotoxicity (CC50>10 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 155 | Get Quote |
|
| 10MG | 245 | Get Quote |
|
| 25MG | 492 | Get Quote |
|
| 50MG | 710 | Get Quote |
|
| 100MG | 972 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAB-423
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NoteResearch use only, not for human use.
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Brief DescriptionAB-423 is a novel potent, class II HBV capsid inhibitor that shows potent inhibition of HBV replication with EC50 of 0.08-0.27 uM, with no significant cytotoxicity (CC50>10 uM).
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DescriptionAB-423 is a novel potent, class II HBV capsid inhibitor that shows potent inhibition of HBV replication with EC50 of 0.08-0.27 uM, with no significant cytotoxicity (CC50>10 uM); inhibits HBV genotypes A through D and nucleos/tide-resistant variants, causes capsid particles devoid of encapsidated pgRNA and rcDNA in treated HepDES19 cells, prevents the conversion of encapsidated rcDNA to cccDNA presumably by interfering with the capsid uncoating process; dose-dependently reduces serum HBV DNA levels in mouse model of HBV model, shows synergistic antiviral activity combined with entecavir (ETV).HBV Infection Phase 1 Clinical
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SynonymsAB423;AB423
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PathwayMicrobiology/Virology
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TargetHBV
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RecptorHBV
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Research AreaInfection
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IndicationHBV Infection
Chemical Information
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CAS Number1572510-80-5
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Formula Weight386.39
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Molecular FormulaC17H17F3N2O3S
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Purity>98% (HPLC)
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SolubilityDMSO : 83.3 mg/mL215.59 mM
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SMILESCCC(C)NS(=O)(=O)C1=CC(=C(C=C1)F)C(=O)NC2=CC(=C(C=C2)F)F
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Chemical Name(R)-5-(N-(sec-butyl)sulfamoyl)-N-(3,4-difluorophenyl)-2-fluorobenzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mani N, et al. Antimicrob Agents Chemother. 2018 Mar 19. pii: AAC.00082-18.
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