3-Methyladenine

Research use only, not for human use.

A selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 uM and 60 uM in HeLa cells.

A selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 uM and 60 uM in HeLa cells; blocks class I PI3K persistently, whereas its suppressive effect on class III PI3K is transient; induces caspase-dependent cell death in HeLa cells, and the death occurs independently of the inhibition of autophagy; also blocks autophagosome formation.

3-MA

PI3K/Akt/mTOR signaling

PI3K

PI3Kγ;Vps34

Cancer

——

5142-23-4

149.15

C6H7N5

>98% (HPLC)

DMSO: ≥ 1.5 mg/mL; DMSO: 6.8 mg/mL (Need ultrasonic); H2O: 8.82 mg/mL (Need ultrasonic)

NC(N=CN1C)=C2C1=NC=N2

3H-Purin-6-amine, 3-methyl-

(-20℃)

With Ice Pack

≥ 2 years