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3-Methyladenine
CAS No. 5142-23-4
3-Methyladenine ( 3-MA )
Catalog No. M14779 CAS No. 5142-23-4
A selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 uM and 60 uM in HeLa cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 32 | In Stock |
|
| 50MG | 43 | In Stock |
|
| 100MG | 73 | In Stock |
|
| 200MG | 126 | In Stock |
|
| 500MG | 239 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name3-Methyladenine
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NoteResearch use only, not for human use.
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Brief DescriptionA selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 uM and 60 uM in HeLa cells.
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DescriptionA selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 uM and 60 uM in HeLa cells; blocks class I PI3K persistently, whereas its suppressive effect on class III PI3K is transient; induces caspase-dependent cell death in HeLa cells, and the death occurs independently of the inhibition of autophagy; also blocks autophagosome formation.
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Synonyms3-MA
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3Kγ;Vps34
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number5142-23-4
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Formula Weight149.15
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Molecular FormulaC6H7N5
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 1.5 mg/mL; DMSO: 6.8 mg/mL (Need ultrasonic); H2O: 8.82 mg/mL (Need ultrasonic)
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SMILESNC(N=CN1C)=C2C1=NC=N2
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Chemical Name3H-Purin-6-amine, 3-methyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Miller S, et al. Autophagy. 2010 Aug;6(6):805-7.
2. Hou H, et al. PLoS One. 2012, 7(4), e35665.
3. Wu YT, et al. J Biol Chem. 2010, 285(14), 10850-10861.
2. Hou H, et al. PLoS One. 2012, 7(4), e35665.
3. Wu YT, et al. J Biol Chem. 2010, 285(14), 10850-10861.
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