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AZD8835
CAS No. 1620576-64-8
AZD8835 ( AZD-8835 )
Catalog No. M12383 CAS No. 1620576-64-8
AZD8835 (AZD-8835) is a potent, selective inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 and 5.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | In Stock |
|
| 5MG | 65 | In Stock |
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| 10MG | 95 | In Stock |
|
| 25MG | 178 | In Stock |
|
| 50MG | 260 | In Stock |
|
| 100MG | 447 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD8835
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NoteResearch use only, not for human use.
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Brief DescriptionAZD8835 (AZD-8835) is a potent, selective inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 and 5.7 nM.
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DescriptionAZD8835 (AZD-8835) is a potent, selective inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 and 5.7 nM, 15-fold and >100-fold selectivity over PI3Kγ and PI3Kβ; also potently inhibits PI3Kα mutants E545K and H1047R with IC50 of 6 nM; preferentially inhibits growth in cells with mutant PIK3CA status inhibits AKT phosphorylation with IC50 of 58 nM in PIK3CA mutant human breast ductal carcinoma BT474 cell line; suppresses tumour growth (93% tumour growth inhibition) in murine H1047R PI3Kα mutated SKOV-3 xenograft tumour model (25mg/kg b.i.d).Breast Cancer Phase 1 Discontinued
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SynonymsAZD-8835
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number1620576-64-8
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Formula Weight469.54
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Molecular FormulaC22H31N9O3
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Purity>98% (HPLC)
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SolubilityDMSO: 16 mg/mL
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SMILESO=C(N1CCC(C2=NN(CC)C(C3=NC(C4=NN=C(C(C)(C)C)O4)=C(N)N=C3)=N2)CC1)CCO
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Chemical Name1-Propanone, 1-[4-[5-[5-amino-6-[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]-2-pyrazinyl]-1-ethyl-1H-1,2,4-triazol-3-yl]-1-piperidinyl]-3-hydroxy-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Barlaam B, et al. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5155-62.
2. Hudson K, et al. Mol Cancer Ther. 2016 May;15(5):877-89.
3. Lynch JT, et al. Oncotarget. 2016 Apr 19;7(16):22128-39.
4. Maynard J, et al. PLoS One. 2017 Aug 14;12(8):e0183048.
2. Hudson K, et al. Mol Cancer Ther. 2016 May;15(5):877-89.
3. Lynch JT, et al. Oncotarget. 2016 Apr 19;7(16):22128-39.
4. Maynard J, et al. PLoS One. 2017 Aug 14;12(8):e0183048.
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