PP121 ( PP 121;PP-121 )

Catalog No. M10353 CAS No. 1092788-83-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PP121
Note

Research use only, not for human use.
Brief Description

A multitargeted, dual tyrosine and PI3K kinase inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl.
Description

A multitargeted, dual tyrosine and PI3K kinase inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2, 8, 10, 12, 14 and 18 nM; also inhibits Ret, VEGFR-2, 110α/mTOR, potently inhibits both tyrosine kinases and PI3Ks but not serine-threonine kinases.
Synonyms

PP 121;PP-121
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

Hck;mTOR;PDGFR;Src;VEGFR
Research Area

Cancer
Indication

——

CAS Number

1092788-83-4
Formula Weight

319.36
Molecular Formula

C17H17N7
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

NC1=C2C(N(C3CCCC3)N=C2C4=CN=C(NC=C5)C5=C4)=NC=N1
Chemical Name

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-

1. Apsel B, et al. Nat Chem Biol. 2008 Nov;4(11):691-9.
2. Che HY, et al. Tumour Biol. 2014 Sep;35(9):8659-64.

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