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PP121
CAS No. 1092788-83-4
PP121 ( PP 121;PP-121 )
Catalog No. M10353 CAS No. 1092788-83-4
A multitargeted, dual tyrosine and PI3K kinase inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 46 | In Stock |
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| 10MG | 70 | In Stock |
|
| 25MG | 140 | In Stock |
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| 50MG | 224 | In Stock |
|
| 100MG | 327 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePP121
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NoteResearch use only, not for human use.
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Brief DescriptionA multitargeted, dual tyrosine and PI3K kinase inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl.
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DescriptionA multitargeted, dual tyrosine and PI3K kinase inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2, 8, 10, 12, 14 and 18 nM; also inhibits Ret, VEGFR-2, 110α/mTOR, potently inhibits both tyrosine kinases and PI3Ks but not serine-threonine kinases.
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SynonymsPP 121;PP-121
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorHck;mTOR;PDGFR;Src;VEGFR
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1092788-83-4
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Formula Weight319.36
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Molecular FormulaC17H17N7
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESNC1=C2C(N(C3CCCC3)N=C2C4=CN=C(NC=C5)C5=C4)=NC=N1
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Chemical Name1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Apsel B, et al. Nat Chem Biol. 2008 Nov;4(11):691-9.
2. Che HY, et al. Tumour Biol. 2014 Sep;35(9):8659-64.
2. Che HY, et al. Tumour Biol. 2014 Sep;35(9):8659-64.
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