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1E7-03

CAS No. 1565845-92-2

1E7-03 ( 1E703; 1E7 03; 1E7-03 )

Catalog No. M12234 CAS No. 1565845-92-2

1E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    1E7-03
  • Note
    Research use only, not for human use.
  • Brief Description
    1E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM).
  • Description
    1E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM); disrupts the interaction of Tat with PP1, inhibits HIV-1 transcription with IC50 of 2 uM, with no cytotoxicity and displays a plasma half-life greater than 8 h in mice; inhibits EBOV transcription and strongly induces VP30 phosphorylation in the N-terminal Ser residues 29-46.
  • Synonyms
    1E703; 1E7 03; 1E7-03
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1565845-92-2
  • Formula Weight
    503.56
  • Molecular Formula
    C28H29N3O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=C(CC/C2=C\C3=CC=C(OC)C(OC)=C3)C2=NC4=CC=CC=C14)OC(C)C(NC(NCC)=O)=O
  • Chemical Name
    1-(3-ethylureido)-1-oxopropan-2-yl (Z)-3-(3,4-dimethoxybenzylidene)-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Carey BD, et al. J Virol. 2018 May 16. pii: JVI.02068-17.
2. Ilinykh PA, et al. J Biol Chem. 2014 Aug 15;289(33):22723-38.
3. Ammosova T, et al. Br J Pharmacol. 2014 Nov;171(22):5059-75.
4. Lin X, et al. Oncotarget. 2017 Aug 7;8(44):76749-76769.
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