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1E7-03
CAS No. 1565845-92-2
1E7-03 ( 1E703; 1E7 03; 1E7-03 )
Catalog No. M12234 CAS No. 1565845-92-2
1E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product Name1E7-03
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NoteResearch use only, not for human use.
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Brief Description1E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM).
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Description1E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM); disrupts the interaction of Tat with PP1, inhibits HIV-1 transcription with IC50 of 2 uM, with no cytotoxicity and displays a plasma half-life greater than 8 h in mice; inhibits EBOV transcription and strongly induces VP30 phosphorylation in the N-terminal Ser residues 29-46.
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Synonyms1E703; 1E7 03; 1E7-03
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research Area——
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Indication——
Chemical Information
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CAS Number1565845-92-2
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Formula Weight503.56
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Molecular FormulaC28H29N3O6
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=C(CC/C2=C\C3=CC=C(OC)C(OC)=C3)C2=NC4=CC=CC=C14)OC(C)C(NC(NCC)=O)=O
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Chemical Name1-(3-ethylureido)-1-oxopropan-2-yl (Z)-3-(3,4-dimethoxybenzylidene)-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Carey BD, et al. J Virol. 2018 May 16. pii: JVI.02068-17.
2. Ilinykh PA, et al. J Biol Chem. 2014 Aug 15;289(33):22723-38.
3. Ammosova T, et al. Br J Pharmacol. 2014 Nov;171(22):5059-75.
4. Lin X, et al. Oncotarget. 2017 Aug 7;8(44):76749-76769.
2. Ilinykh PA, et al. J Biol Chem. 2014 Aug 15;289(33):22723-38.
3. Ammosova T, et al. Br J Pharmacol. 2014 Nov;171(22):5059-75.
4. Lin X, et al. Oncotarget. 2017 Aug 7;8(44):76749-76769.
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