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Amyloids
Amyloid fibers are distinguished by their resistance to proteinase K, tinctorial properties and β-sheet-rich secondary structure.Amyloid fibrils have biochemical and biophysical properties that distinguish them from other biological polymers. Amyloid formation is a hallmark of many human diseases including Alzheimer’s, Huntington’s and the prion diseases. Therefore, understanding amyloidogenesis will provide insights into the development of therapeutics that target these debilitating diseases. The deposition of large amounts of fibrillar material can subvert the tissue architecture and consequently cause organ dysfunction. Amyloid fibrils may also cause organ dysfunction by interacting with local receptors, such as RAGE. In Alzheimer’s disease, an inflammatory response in the cerebral cortex elicited by the progressive accumulation of Ab contributes to the pathogenesis of the disease.At present, the most effective approach to the treatment of the systemic amyloidoses involves shutting down or substantially reducing the synthesis of the amyloid precursor.
References
1.Neal D. Hammer,et al. J Alzheimers Dis. 2008 May; 13(4): 407–419.
2.Merlini G,et al. N Engl J Med. 2003 Aug 7;349(6):583-96.
References
1.Neal D. Hammer,et al. J Alzheimers Dis. 2008 May; 13(4): 407–419.
2.Merlini G,et al. N Engl J Med. 2003 Aug 7;349(6):583-96.
Others
Amyloids
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BNC-1
catalog no : M16864
cas no: 96335-59-0
BNC-1 is a small molecule modulator of Amyloid pathology by promoting phosphorylation and activation of Elk-1.
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TDI-2760
catalog no : M16824
cas no: 956128-08-8
TDI-2760 si a small molecule Aβ-aggregation inhibitor that not only shows a strong inhibitory efficacy toward the Aβ-fibrinogen interaction.
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SEN 1269
catalog no : M16823
cas no: 956128-01-1
SEN1269 is a novel potent Aβ aggregation inhibitor that binds to monomeric Aβ1-42 with Kd of 4.4 uM.
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FPS-ZM1
catalog no : M16776
cas no: 945714-67-0
FPS-ZM1 is a high-affinity RAGE-specific inhibitor.
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TH-237A
catalog no : M16689
cas no: 935467-97-3
A novel, brain penetrant neuroprotective agent that protects neurons against β-amyloid (Aβ) induced neurotoxicity.