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AAK1
The adaptor-associated kinase 1 (AAK1) is originally identified as an alpha-adaptin binding protein. AAK1 is a serine/threonine kinase that is thought to coordinate the recruitment of AP-2 to receptors containing tyrosine-based internalization motifs by phosphorylating the μ2 subunit, AAK1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its rapid recycling back to the plasma membrane from early/sorting endosome.
References:
1.Henderson DM, et al. Mol Biol Cell. 2007 Jul;18(7):2698-706.
2.Ultanir SK,et al. Neuron. 2012 Mar 22;73(6):1127-42.
References:
1.Henderson DM, et al. Mol Biol Cell. 2007 Jul;18(7):2698-706.
2.Ultanir SK,et al. Neuron. 2012 Mar 22;73(6):1127-42.
Others
AAK1
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AAK1 inhibitor 25A
catalog no : M16970
cas no: ——
AAK1 inhibitor 25A is a potent, selective inhibitor of AAK1 and the closely related kinase BMP2K with Ki of 8 nM (AAK1).
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AAK1 inhibitor 1
catalog no : M13613
cas no: 2247894-32-0
AAK1 inhibitor 1 (SGC-AAK1-1) is a potent, selective inhibitor of AAK1 and BMP2K/BIKE.
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BMS-901715
catalog no : M12595
cas no: 1699861-37-4
BMS-901715 (BMS901715) is a?potent, selective adapter protein-2 associated kinase 1 (AAK1) inhibitor.
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BMT-090605
catalog no : M12203
cas no: 1551403-51-0
BMT-090605 (BMT 090605, BMT090605)?is a potent, selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 0.6 nM.
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BMT-046091
catalog no : M12202
cas no: 1551401-20-7
BMT-046091 (BMT046091) is a potent and selective AAK1 inhibitor with IC50 of 2.8 nM.