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Syk
Spleen tyrosine kinase (Syk) is a cytosolic non-receptor protein tyrosine kinase (PTK). Syk contains two N-terminal SH2 domains and one Cterminal tyrosine kinase domain. The SH2 domains of Syk bind to immunoreceptor tyrosine-based activation motifs (ITAMs), leading to Syk activation. Syk protein lacks myristoylation site, therefore does not attach directly to the cell membrane.Syk was recognized as a critical element in the BCR signaling pathway. Syk along with other BCR signaling molecules, Bruton tyrosine kinase (BTK), PI3K delta (PI3Kδ), and tumor necrosis factor (TNF) superfamily receptors was also found to be involved in signal transduction independent from the BCR. Syk is expressed primarily in hematopoietic cells like Bcells, monocytes, macrophages, mast cells, and neutrophils. Syk was recognized to be a potential target for the treatment of various hematologic cancers, autoimmune disorders, and other inflammatory states.
References
1.Liu D,et al. J Hematol Oncol. 2017;10(1):145.
References
1.Liu D,et al. J Hematol Oncol. 2017;10(1):145.
Angiogenesis
Syk
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Sovleplenib
catalog no : M34619
cas no: 1415792-84-5
Sovleplenib (HMPL523) is an orally available, selective and potent inhibitor of the splenic tyrosine kinase SYK with an IC50 of 25 nM.Sovleplenib has antitumor activity and may be used in studies of immune thrombocytopenia (ITP).
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TC-S 7003
catalog no : M33407
cas no: 847950-09-8
TC-S 7003 (Lck Inhibitor) is an orally active, selective and potent lymphocyte kinase (Lck) inhibitor with anti-inflammatory activity, inhibition of Lck, Lyn, Src, and Syk kinases, and inhibition of T-cell proliferation, and may be useful in the study of arthritis.
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Syk-IN-3
catalog no : M33132
cas no: 1312534-69-2
Syk-IN-3 is a Syk inhibitor with potential anti-inflammatory and anticancer activity and can be used to study immune dysregulation.
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Cevidoplenib dimesylate hydrochloride
catalog no : M28906
cas no: 269062-93-3
Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory properties.
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Cevidoplenib dimesylate
catalog no : M28223
cas no: 2043659-93-2
Cevidoplenib dimesylate is an inhibitor of spleen tyrosine kinase (Syk), possessing anti-inflammatory and immunomodulating properties.