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GW297361

CAS No. 388627-21-2

GW297361( —— )

Catalog No. M36628 CAS No. 388627-21-2

GW297361 is a potent inhibitor of the cell cycle protein-dependent kinase Cdk1 and also inhibits the Pho85 signaling pathway.The IC50s of GW297361 on yeast Cdk1 and Pho85 were 20 nM and 400 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GW297361
  • Note
    Research use only, not for human use.
  • Brief Description
    GW297361 is a potent inhibitor of the cell cycle protein-dependent kinase Cdk1 and also inhibits the Pho85 signaling pathway.The IC50s of GW297361 on yeast Cdk1 and Pho85 were 20 nM and 400 nM, respectively.
  • Description
    GW297361 is an oxindole CDK inhibitor that elicits a Pho85-selective response in cells. GW297361 inhibits yeast Cdk1 and Pho85 with IC50s of 20 nM and 400 nM in vitro, respectively.
  • In Vitro
    Western Blot Analysis Cell Line:YRP1 cells Concentration:20 μM Incubation Time:20 μM Result:An intermediate level of the Orc6 was converted to the faster-migrating isoform (lower:upper = 2:1).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    VEGFR
  • Recptor
    VEGFR | Src | CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    388627-21-2
  • Formula Weight
    372.42
  • Molecular Formula
    C16H12N4O3S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (268.51 mM; Ultrasonic )
  • SMILES
    C(NC1=CC=C(S(N)(=O)=O)C=C1)=C2C=3C4=C(C=CC3NC2=O)N=CS4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kung C, et al. Selective kinase inhibition by exploiting differential pathway sensitivity. Chem Biol. 2006 Apr;13(4):399-407.?
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