β-Elemene

Research use only, not for human use.

β-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.β-Elemene significantly inhibited the metastatic capacity of MDR gastric cells in vivo and in vitro.?Mechanistically, β-Elemene regulated MMP-2/9 expression and reversed epithelial-mesenchymal transition.?

β-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.β-Elemene significantly inhibited the metastatic capacity of MDR gastric cells in vivo and in vitro.?Mechanistically, β-Elemene regulated MMP-2/9 expression and reversed epithelial-mesenchymal transition.?β-Elemene upregulated Cbl-b expression, resulting in inhibition of the EGFR-ERK/AKT pathways, which regulate MMP-2/9.?β-Elemene upregulated Cbl-b by inhibiting miR-1323 expression.?Numbers of metastatic tumor nodules were significantly decreased in the lungs of nude mice after β-Elemene treatment.?β-Elemene inhibits the metastasis of MDR gastric cancer cells by modulating the miR-1323/Cbl-b/EGFR signaling axis.

(-)-β-Elemene,Levo-β-elemene

Apoptosis

Apoptosis

Apoptosis

cancer

Anaplastic Oligoastrocytoma|Anaplastic Astrocytoma|Glioblastoma

515-13-9

204.35

C15H24

>98% (HPLC)

DMSO:50 mg/mL (244.68 mM; Need ultrasonic)

CC([C@H]1[C@@](C)(CC[C@@H](C(C)=C)C1)C=C)=C

——

(-20℃)

With Ice Pack

≥ 2 years