Cart
sales@molnova.com
NS3694
CAS No. 426834-38-0
NS3694 ( —— )
Catalog No. M27510 CAS No. 426834-38-0
NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | Get Quote |
|
| 5MG | 65 | Get Quote |
|
| 10MG | 102 | Get Quote |
|
| 25MG | 215 | Get Quote |
|
| 50MG | 312 | Get Quote |
|
| 100MG | 484 | Get Quote |
|
| 500MG | 1035 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameNS3694
-
NoteResearch use only, not for human use.
-
Brief DescriptionNS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.
-
DescriptionNS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.(In Vitro):NS3694 (10, 50, and 100 μM) specifically inhibits cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9. In MCF-casp3 cells, NS3694 (10-100 μM) inhibits dose-dependently caspase 9, 3, and 7 processing, DFF45/ICAD, and PARP cleavage, and DEVDase activity and inhibits TNF-induced effector caspase activation and apoptosis.
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
Recptornon-cleavable ADC linker;Alkyl-Chain
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number426834-38-0
-
Formula Weight358.7
-
Molecular FormulaC15H10ClF3N2O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(O)C1=CC=C(Cl)C=C1NC(=O)NC2=CC=CC(=C2)C(F)(F)F
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
molnova catalog
related products
-
SW-106065
SW-106065 is a novel pharmacologic inducer of apoptosis in MPNST (malignant peripheral nerve sheath tumors).
-
Cl-amidine hydrochlo...
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4).
-
Ecdysone
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.
