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NS3694
CAS No. 426834-38-0
NS3694 ( —— )
Catalog No. M27510 CAS No. 426834-38-0
NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | Get Quote |
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| 5MG | 65 | Get Quote |
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| 10MG | 102 | Get Quote |
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| 25MG | 215 | Get Quote |
|
| 50MG | 312 | Get Quote |
|
| 100MG | 484 | Get Quote |
|
| 500MG | 1035 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameNS3694
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NoteResearch use only, not for human use.
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Brief DescriptionNS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.
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DescriptionNS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.(In Vitro):NS3694 (10, 50, and 100 μM) specifically inhibits cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9. In MCF-casp3 cells, NS3694 (10-100 μM) inhibits dose-dependently caspase 9, 3, and 7 processing, DFF45/ICAD, and PARP cleavage, and DEVDase activity and inhibits TNF-induced effector caspase activation and apoptosis.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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Recptornon-cleavable ADC linker;Alkyl-Chain
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Research Area——
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Indication——
Chemical Information
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CAS Number426834-38-0
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Formula Weight358.7
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Molecular FormulaC15H10ClF3N2O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)C1=CC=C(Cl)C=C1NC(=O)NC2=CC=CC(=C2)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
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