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mPGES1-IN-16
CAS No. 1915003-93-8
mPGES1-IN-16( —— )
Catalog No. M13001 CAS No. 1915003-93-8
mPGES1-IN-16 is a potent and selective mPGES-1 inhibitor with IC50 of 1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamemPGES1-IN-16
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NoteResearch use only, not for human use.
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Brief DescriptionmPGES1-IN-16 is a potent and selective mPGES-1 inhibitor with IC50 of 1 nM.
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DescriptionmPGES1-IN-16 is a potent and selective mPGES-1 inhibitor with IC50 of 1 nM; displays no activity against a panel of 35 receptors, ion channels, and hERG; shows IC50/IC80 of 6 nM/24 nM for inhibition of PGE2 formation in vitro in LPS-stimulated human whole blood (HWB); orally bioavailable in vivo.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetPGE synthase
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RecptorPGE synthase
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Research Area——
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Indication——
Chemical Information
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CAS Number1915003-93-8
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Formula Weight485.628
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Molecular FormulaC30H35N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name2-(2-((1S,2S)-2-(1-(8-methylquinolin-2-yl)piperidine-4-carboxamido)cyclopentyl)ethyl)benzoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Partridge KM, et al. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1478-1483.
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