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Crisdesalazine
CAS No. 927685-43-6
Crisdesalazine( AAD-2004 | AAD2004 )
Catalog No. M16640 CAS No. 927685-43-6
Crisdesalazine (AAD-2004, AAD2004) is a derivative of aspirin that inhibits microsomal PGE(2) synthase-1 (mPGES-1) activity in response to both LPS-treated BV2 cell with IC50 of 230 nM and recombinant human mPGES-1 protein with IC50 of 249 nM in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 393 | Get Quote |
|
| 10MG | 581 | Get Quote |
|
| 25MG | 888 | Get Quote |
|
| 50MG | 1242 | Get Quote |
|
| 100MG | 1674 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCrisdesalazine
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NoteResearch use only, not for human use.
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Brief DescriptionCrisdesalazine (AAD-2004, AAD2004) is a derivative of aspirin that inhibits microsomal PGE(2) synthase-1 (mPGES-1) activity in response to both LPS-treated BV2 cell with IC50 of 230 nM and recombinant human mPGES-1 protein with IC50 of 249 nM in vitro.
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DescriptionCrisdesalazine (AAD-2004, AAD2004) is a derivative of aspirin that inhibits microsomal PGE(2) synthase-1 (mPGES-1) activity in response to both LPS-treated BV2 cell with IC50 of 230 nM and recombinant human mPGES-1 protein with IC50 of 249 nM in vitro; blocked free radical production, PGE(2) formation, and microglial activation in the spinal cords in superoxide dismutase 1(G93A) transgenic mouse model of ALS, reduced autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and increasing life span, which is superior to riluzole or ibuprofen.Alzheimer Disease Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsAAD-2004 | AAD2004
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PathwayImmunology/Inflammation
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TargetPGE synthase
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RecptorPGE synthase
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number927685-43-6
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Formula Weight325.287
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Molecular FormulaC16H14F3NO3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)C1=CC(NCCC2=CC=C(C(F)(F)F)C=C2)=CC=C1O
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Chemical Name2-hydroxy-5-({2-[4-(trifluoromethyl)phenyl]ethyl}amino)benzoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shin JH, et al. J Neurochem. 2012 Sep;122(5):952-61.
2. Baek IS, et al. Exp Neurobiol. 2013 Mar;22(1):31-7.
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