MF63

CAS No. 892549-43-8

MF63 ( MF 63;MF-63 )

Catalog No. M16436 CAS No. 892549-43-8

MF63 is a potent, selective, and orally active mPGES-1 inhibitor with IC50 of 1.3 nM for human mPGES-1 enzyme.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MF63
  • Note
    Research use only, not for human use.
  • Brief Description
    MF63 is a potent, selective, and orally active mPGES-1 inhibitor with IC50 of 1.3 nM for human mPGES-1 enzyme.
  • Description
    MF63 is a potent, selective, and orally active mPGES-1 inhibitor with IC50 of 1.3 nM for human mPGES-1 enzyme, >1000-fold selectivity over other prostanoid synthases; strongly inhibits guinea pig mPGES-1 (IC50= 0.9 nM) but not the mouse or rat enzyme; selectively suppresses the synthesis of PGE(2), but not other prostaglandins inhibitable by NSAIDs, yet retains NSAID-like efficacy at inhibiting LPS-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain, relieves pyresis and pain in preclinical models of inflammation.
  • Synonyms
    MF 63;MF-63
  • Pathway
    Immunology/Inflammation
  • Target
    PGE synthase
  • Recptor
    PGE synthase
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    892549-43-8
  • Formula Weight
    378.80
  • Molecular Formula
    C23H11ClN4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 43 mg/mL
  • SMILES
    N#CC1=CC=CC(C#N)=C1C2=NC3=C4C=CC(Cl)=CC4=C5C=CC=CC5=C3N2
  • Chemical Name
    1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xu D, et al. J Pharmacol Exp Ther. 2008 Sep;326(3):754-63.
2. Cté B, et al. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6816-20.
3. Giroux A, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5837-41.
4. Finetti F, et al. Endocr Relat Cancer. 2015 Aug;22(4):665-78.
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