MF63
CAS No. 892549-43-8
MF63 ( MF 63;MF-63 )
Catalog No. M16436 CAS No. 892549-43-8
MF63 is a potent, selective, and orally active mPGES-1 inhibitor with IC50 of 1.3 nM for human mPGES-1 enzyme.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
50MG | 647 | Get Quote |
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100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameMF63
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NoteResearch use only, not for human use.
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Brief DescriptionMF63 is a potent, selective, and orally active mPGES-1 inhibitor with IC50 of 1.3 nM for human mPGES-1 enzyme.
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DescriptionMF63 is a potent, selective, and orally active mPGES-1 inhibitor with IC50 of 1.3 nM for human mPGES-1 enzyme, >1000-fold selectivity over other prostanoid synthases; strongly inhibits guinea pig mPGES-1 (IC50= 0.9 nM) but not the mouse or rat enzyme; selectively suppresses the synthesis of PGE(2), but not other prostaglandins inhibitable by NSAIDs, yet retains NSAID-like efficacy at inhibiting LPS-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain, relieves pyresis and pain in preclinical models of inflammation.
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SynonymsMF 63;MF-63
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PathwayImmunology/Inflammation
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TargetPGE synthase
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RecptorPGE synthase
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number892549-43-8
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Formula Weight378.80
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Molecular FormulaC23H11ClN4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 43 mg/mL
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SMILESN#CC1=CC=CC(C#N)=C1C2=NC3=C4C=CC(Cl)=CC4=C5C=CC=CC5=C3N2
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Chemical Name1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xu D, et al. J Pharmacol Exp Ther. 2008 Sep;326(3):754-63.
2. Cté B, et al. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6816-20.
3. Giroux A, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5837-41.
4. Finetti F, et al. Endocr Relat Cancer. 2015 Aug;22(4):665-78.
2. Cté B, et al. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6816-20.
3. Giroux A, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5837-41.
4. Finetti F, et al. Endocr Relat Cancer. 2015 Aug;22(4):665-78.
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