m-PEG12-OH( Dodecaethylene Glycol Monomethyl Ether )

Catalog No. M26969 CAS No. 2050595-03-2

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Datasheet

HNMR

HPLC

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Product Name

m-PEG12-OH
Note

Research use only, not for human use.
Brief Description

m-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Description

m-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
In Vivo

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Synonyms

Dodecaethylene Glycol Monomethyl Ether
Pathway

Others
Target

Other Targets
Recptor

DENV NS2B-NS3 protease
Research Area

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Indication

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1.Watowich, Stanley J, et al. SMALL-MOLECULE INHIBITORS OF DENGUE VIRUS PROTEASES. US20150141521A1.

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