inh-02( RNF5 inhibitor inh-02 )

Catalog No. M14053 CAS No. 324579-65-9

COA

Datasheet

HNMR

HPLC

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Product Name

inh-02
Note

Research use only, not for human use.
Brief Description

inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1.
Description

inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1; causes significant F508del-CFTR rescue (EC50=2.2 uM) in immortalized and primary bronchial epithelial cells from CF patients homozygous for the F508del mutation, decreases ubiquitylation of mutant CFTR, causing stabilization of the mature form of CFTR; inh-2 acts on ATG4B and paxillin, which are known targets downstream of RNF5.
In Vitro

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In Vivo

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Synonyms

RNF5 inhibitor inh-02
Pathway

Proteasome/Ubiquitin
Target

E3 Ubiquitin Ligase
Recptor

E3 Ubiquitin Ligase
Research Area

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Indication

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CAS Number

324579-65-9
Formula Weight

384.501
Molecular Formula

C23H20N4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 83.33 mg/mL (216.72 mM)
SMILES

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Chemical Name

(E)-N-((Z)-4-benzyl-3-methyl-1,2,4-thiadiazol-5(4H)-ylidene)-N'-phenylbenzimidamide

1. Sondo E, et al. Cell Chem Biol. 2018 Apr 26. pii: S2451-9456(18)30124-7.

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