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Home - Products - Proteasome/Ubiquitin - E3 Ubiquitin Ligase - Apcin

Apcin

CAS No. 300815-04-7

Apcin( Apcin )

Catalog No. M13933 CAS No. 300815-04-7

Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Apcin
  • Note
    Research use only, not for human use.
  • Brief Description
    Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor.
  • Description
    Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates; shows enhanced anti-MM activity combined with another APC/C inhibitor proTAME.
  • In Vitro
    Apoptosis AnalysisCell Line:HMCLs LP-1 and RPMI-8226 cells Concentration:25, 50 μM Incubation Time:48 hoursResult:Had minor effects on multiple myeloma (MM) cells alone and significantly increased MM apoptosis combining with proTAME (6, 12 μM).Western Blot Analysis Cell Line:HeLa cells with Nocodazole (100?nM) Concentration:25?μM .Incubation Time:2-14 hours Result:Induced slippage more slowly, as indicated by Cdc27 dephosphorylation and a reduction in cyclin B1, securin and phosphoH3 levels beginning 4-6h after mitotic entry.
  • In Vivo
    ——
  • Synonyms
    Apcin
  • Pathway
    Proteasome/Ubiquitin
  • Target
    E3 Ubiquitin Ligase
  • Recptor
    E3 Ubiquitin Ligase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    300815-04-7
  • Formula Weight
    438.65
  • Molecular Formula
    C13H14Cl3N7O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (284.97 mM)
  • SMILES
    CC1=NC=C([N+]([O-])=O)N1CCOC(NC(C(Cl)(Cl)Cl)NC2=NC=CC=N2)=O
  • Chemical Name
    [2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-carbamic acid, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sackton KL, et al. Nature. 2014 Oct 30;514(7524):646-9. 2. de Lange J, et al. Nat Commun. 2015 Oct 1;6:8399. 3. Lub S, et al. Oncotarget. 2016 Jan 26;7(4):4062-76.
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