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iCRT-5

CAS No. 18623-44-4

iCRT-5( iCRT5 )

Catalog No. M12878 CAS No. 18623-44-4

iCRT-5 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 18 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    iCRT-5
  • Note
    Research use only, not for human use.
  • Brief Description
    iCRT-5 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 18 nM.
  • Description
    iCRT-5 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 18 nM; specifically modulates the nuclear transcriptional activity of β-catenin while not affecting its cytoskeletal function in stabilizing adherens junctions at the cell membrane; blocks Wnt/β-catenin-induced target genes and phenotypes in various mammalian and cancer cell lines.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    iCRT5
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Beta-catenin
  • Recptor
    Beta-catenin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    18623-44-4
  • Formula Weight
    367.44
  • Molecular Formula
    C16H17NO5S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 36 mg/mL (97.98 mM)
  • SMILES
    O=C(O)CCCN(C/1=O)C(SC1=C/C2=CC=C(OC)C(OC)=C2)=S
  • Chemical Name
    (Z)-4-(5-(3,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gonsalves FC, et al. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):5954-63. 2. Anastas JN, et al. Nat Rev Cancer. 2013 Jan;13(1):11-26.
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