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KYA-1797K
CAS No. 1956356-56-1
KYA-1797K( KYA 1797K )
Catalog No. M13063 CAS No. 1956356-56-1
A derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 37 | In Stock |
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| 5MG | 60 | In Stock |
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| 10MG | 105 | In Stock |
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| 25MG | 231 | In Stock |
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| 50MG | 393 | In Stock |
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| 100MG | 583 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameKYA-1797K
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NoteResearch use only, not for human use.
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Brief DescriptionA derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling.
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DescriptionA derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling; dose-dependently decreases Wnt3a-CM-induced TOPflash reporter activation with IC50 of 0.75 uM; more effectively reduces the levels of both β-catenin and pan-Ras as well as the activities of ERK and Akt in SW480 cells; binds to Axin (Kd to WT axin-RGS=0.29 uM) and destabilizes b-catenin and Ras; inhibits growth of CRC cells with GI50 of 4-5 uM; suppresses the tumors induced by APC and KRAS mutations in tumor xenograft mice (25 mg/kg, i.p.).
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In Vitro——
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In Vivo——
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SynonymsKYA 1797K
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PathwayWnt/Notch/Hedgehog
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TargetBeta-catenin
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RecptorWnt/β-catenin
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1956356-56-1
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Formula Weight442.501
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Molecular FormulaC17H11KN2O6S2
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Purity>98% (HPLC)
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SolubilityEthanol: <1 mg/mL; DMSO: 20 mg/mL (45.2 mM); Water: 20 mg/mL (45.2 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C([O-])CCN(C/1=O)C(SC1=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)=S.[K+]
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Chemical Namepotassium (Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cha PH, et al. Nat Chem Biol. 2016 Aug;12(8):593-600.
2. Cha PH, et al. BMB Rep. 2016 Sep;49(9):455-6.
molnova catalog
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KYA-1797K
A derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling.
