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PKF118-310
CAS No. 84-82-2
PKF118-310( Toxoflavin | Xanthothricin | NSC 67078 )
Catalog No. M16158 CAS No. 84-82-2
A novel small molecule inhibitor of Wnt/beta-catenin signaling that selectively disrupts β-catenin/Tcf4 interaction and inhibits its transcriptional activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 82 | Get Quote |
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| 10MG | 141 | Get Quote |
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| 25MG | 292 | Get Quote |
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| 50MG | 439 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePKF118-310
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NoteResearch use only, not for human use.
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Brief DescriptionA novel small molecule inhibitor of Wnt/beta-catenin signaling that selectively disrupts β-catenin/Tcf4 interaction and inhibits its transcriptional activity.
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DescriptionA novel small molecule inhibitor of Wnt/beta-catenin signaling that selectively disrupts β- catenin/Tcf4 interaction and inhibits its transcriptional activity; produces in vitro antitumor activity in a panel of cancer cells, reduces β-catenin nuclear localization and induces apoptosis, and inhibits expression of Tcf4 responsive genes.
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In VitroToxoflavin (Xanthothricin) exhibits dose-dependent cytotoxicity against the 3 hepatoma cell lines, and with IC50s of 0.66 μM, 0.36 μM and 0.98 μM for Hep40 cells, HepG2 cells and Huh7 cells respectively.
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In Vivo——
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SynonymsToxoflavin | Xanthothricin | NSC 67078
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PathwayWnt/Notch/Hedgehog
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TargetBeta-catenin
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RecptorBeta-catenin
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Research Area——
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Indication——
Chemical Information
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CAS Number84-82-2
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Formula Weight193.16
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Molecular FormulaC7H7N5O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (129.43 mM)
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SMILESO=C(C1=NC=NN(C)C1=N2)N(C)C2=O
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Chemical Name1,6-dimethyl-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lu W, et al. Eur J Pharmacol. 2009 Jan 5;602(1):8-14.
2. Martinez-Font E, et al. Mol Cancer Ther. 2017 Jun;16(6):1166-1176.
3. Franci G, et al. Epigenetics. 2017 Mar 4;12(3):198-205.
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