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Home - Products - Wnt/Notch/Hedgehog - Beta-catenin - PKF118-310

PKF118-310

CAS No. 84-82-2

PKF118-310( Toxoflavin | Xanthothricin | NSC 67078 )

Catalog No. M16158 CAS No. 84-82-2

A novel small molecule inhibitor of Wnt/beta-catenin signaling that selectively disrupts β-catenin/Tcf4 interaction and inhibits its transcriptional activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 92 In Stock
5MG 86 In Stock
10MG 149 In Stock
25MG 307 In Stock
50MG 454 In Stock
100MG 662 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    PKF118-310
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel small molecule inhibitor of Wnt/beta-catenin signaling that selectively disrupts β-catenin/Tcf4 interaction and inhibits its transcriptional activity.
  • Description
    A novel small molecule inhibitor of Wnt/beta-catenin signaling that selectively disrupts β- catenin/Tcf4 interaction and inhibits its transcriptional activity; produces in vitro antitumor activity in a panel of cancer cells, reduces β-catenin nuclear localization and induces apoptosis, and inhibits expression of Tcf4 responsive genes.
  • In Vitro
    Toxoflavin (Xanthothricin) exhibits dose-dependent cytotoxicity against the 3 hepatoma cell lines, and with IC50s of 0.66 μM, 0.36 μM and 0.98 μM for Hep40 cells, HepG2 cells and Huh7 cells respectively.
  • In Vivo
    ——
  • Synonyms
    Toxoflavin | Xanthothricin | NSC 67078
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Beta-catenin
  • Recptor
    Beta-catenin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    84-82-2
  • Formula Weight
    193.16
  • Molecular Formula
    C7H7N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (129.43 mM)
  • SMILES
    O=C(C1=NC=NN(C)C1=N2)N(C)C2=O
  • Chemical Name
    1,6-dimethyl-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lu W, et al. Eur J Pharmacol. 2009 Jan 5;602(1):8-14. 2. Martinez-Font E, et al. Mol Cancer Ther. 2017 Jun;16(6):1166-1176. 3. Franci G, et al. Epigenetics. 2017 Mar 4;12(3):198-205.
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