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Home - Products - Wnt/Notch/Hedgehog - Beta-catenin - PKF118-310

PKF118-310

CAS No. 84-82-2

PKF118-310( Toxoflavin | Xanthothricin | NSC 67078 )

Catalog No. M16158 CAS No. 84-82-2

A novel small molecule inhibitor of Wnt/beta-catenin signaling that selectively disrupts β-catenin/Tcf4 interaction and inhibits its transcriptional activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PKF118-310
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel small molecule inhibitor of Wnt/beta-catenin signaling that selectively disrupts β-catenin/Tcf4 interaction and inhibits its transcriptional activity.
  • Description
    A novel small molecule inhibitor of Wnt/beta-catenin signaling that selectively disrupts β- catenin/Tcf4 interaction and inhibits its transcriptional activity; produces in vitro antitumor activity in a panel of cancer cells, reduces β-catenin nuclear localization and induces apoptosis, and inhibits expression of Tcf4 responsive genes.
  • In Vitro
    Toxoflavin (Xanthothricin) exhibits dose-dependent cytotoxicity against the 3 hepatoma cell lines, and with IC50s of 0.66 μM, 0.36 μM and 0.98 μM for Hep40 cells, HepG2 cells and Huh7 cells respectively.
  • In Vivo
    ——
  • Synonyms
    Toxoflavin | Xanthothricin | NSC 67078
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Beta-catenin
  • Recptor
    Beta-catenin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    84-82-2
  • Formula Weight
    193.16
  • Molecular Formula
    C7H7N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (129.43 mM)
  • SMILES
    O=C(C1=NC=NN(C)C1=N2)N(C)C2=O
  • Chemical Name
    1,6-dimethyl-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lu W, et al. Eur J Pharmacol. 2009 Jan 5;602(1):8-14. 2. Martinez-Font E, et al. Mol Cancer Ther. 2017 Jun;16(6):1166-1176. 3. Franci G, et al. Epigenetics. 2017 Mar 4;12(3):198-205.
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