
dTRIM24
CAS No. 2170695-14-2
dTRIM24( dTRIM 24 | dTRIM24 | dTRIM-24 )
Catalog No. M13466 CAS No. 2170695-14-2
dTRIM24 is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement).
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 260 | Get Quote |
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10MG | 410 | Get Quote |
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25MG | 678 | Get Quote |
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50MG | 954 | Get Quote |
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100MG | 1287 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NamedTRIM24
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NoteResearch use only, not for human use.
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Brief DescriptiondTRIM24 is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement).
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DescriptiondTRIM24 is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement).
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In VitrodTRIM24 is a degrader of TRIM24 bromodomain. Recruitment of the VHL E3 ubiquitin ligase by dTRIM24 elicits potent and selective degradation of TRIM24. The anti-proliferative consequences of chemical degradation versus inhibition of TRIM24 are assessed. Growth over time is determined for MOLM-13 cells treated with dTRIM24, IACS-9571, VL-269, and eTRIM24. dTRIM24 suppresses growth to a greater extent than does IACS-9571, accompanied by apoptosis measured as enhanced PARP cleavage. In agreement with a sustained proliferative defect observed following dTRIM24 treatment, near-complete degradation of TRIM24 is observed in dTRIM24-treated cells throughout the duration of the experiment.
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In Vivo——
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SynonymsdTRIM 24 | dTRIM24 | dTRIM-24
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PathwayPROTACs
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TargetPROTAC
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RecptorPROTAC
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Research Area——
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Indication——
Chemical Information
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CAS Number2170695-14-2
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Formula Weight1113.312
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Molecular FormulaC55H68N8O13S2
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Purity>98% (HPLC)
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SolubilityEthanol : < 1 mg/mL
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SMILESO=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C2=CC=CC(S(=O)(NC3=C(OC4=CC=CC(OCCC)=C4)C=C(C(N5C)=C3)N(C)C5=O)=O)=C2)=O)=O)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6
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Chemical Name(2S,4R)-1-((S)-15-(tert-butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1 -benzo[ ]imidazol-5-yl)sulfamoyl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy- (4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gechijian LN, et al. Nat Chem Biol. 2018 Mar 5. doi: 10.1038/s41589-018-0010-y.
molnova catalog



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