GSK983 ( GSK-983;GSK 983 )

Catalog No. M16075 CAS No. 827591-02-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK983
Note

Research use only, not for human use.
Brief Description

GSK983 (GSK-983) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells with DC50 value of 1.5 nM and 3 nM, respectively.
Description

GSK983 (GSK-983) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells with DC50 value of 1.5 nM and 3 nM, respectively; also potently induces robust and concentration-dependent degradation of PCAF and GCN5 in both macrophages and monocyte-derived dendritic cells (DCs), potently modulate the expression of multiple inflammatory mediators in LPS-stimulated macrophages and dendritic cells.
Synonyms

GSK-983;GSK 983
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

——
Indication

——

CAS Number

827591-02-6
Formula Weight

895.86
Molecular Formula

C45H51BrN8O7
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N[C@H]1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)C4=NC=CC=C4
Chemical Name

4-(5-((5-bromo-1-methyl-6-oxo-1,6-dihydropyridazin-4-yl)amino)-1-methylpiperidin-3-yl)-N-(3-((4-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)propyl)phenyl)(methyl)amino)propyl)-N-methylbenzamide

1. Bassi ZI, et al. ACS Chem Biol. 2018 Oct 19;13(10):2862-2867.

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