alpha-Amanitin ( α-Amanitin;α-Amatoxin )

Catalog No. M13648 CAS No. 23109-05-9

α-Amanitin, an 8-Aa cyclic peptide, is an selective inhibitor of RNA polymerase II and III; a suitable toxic ADC payload for antibody-drug conjugates design.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

alpha-Amanitin
Note

Research use only, not for human use.
Brief Description

α-Amanitin, an 8-Aa cyclic peptide, is an selective inhibitor of RNA polymerase II and III; a suitable toxic ADC payload for antibody-drug conjugates design.
Description

α-Amanitin, an 8-Aa cyclic peptide, is an selective inhibitor of RNA polymerase II and III; a suitable toxic ADC payload for antibody-drug conjugates design.
Synonyms

α-Amanitin;α-Amatoxin
Pathway

Antibody Drug Conjugates (ADC)
Target

ADC Cytotoxin
Recptor

ADC Cytotoxin
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

23109-05-9
Formula Weight

918.97
Molecular Formula

C39H54N10O14S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CCC(C)C1C(=O)NCC(=O)NC2CS(=O)C3=C(CC(C(=O)NCC(=O)N1)NC(=O)C(NC(=O)C4CC(CN4C(=O)C(NC2=O)CC(=O)N)O)C(C)C(CO)O)C5=C(N3)C=C(C=C5)O
Chemical Name

α-Amanitin

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Davis MT, et al. Science. 1981 Sep 18;213(4514):1385-8.
2. Kume K, et al. Sci Rep. 2016 May 16;6:25895.
3. Wagner SD, et al. EMBO J. 2013 Mar 20;32(6):781-90.

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