Daun02

Research use only, not for human use.

Daun02 a prodrug that is converted by β-galactosidase to Daunorubicin, inactivate activated neurons that express both β-galactosidase and Fos.

Daun02 a prodrug that is converted by β-galactosidase to Daunorubicin, inactivate activated neurons that express both β-galactosidase and Fos, specifically attenuates cocaine-induced locomotor activity, also attenuates cocaine-induced β-galactosidase expression; daunorubicin, the active product of Daun02 metabolism by β-galactosidase, decreases the activity of MSNs in rat brain slices and that Daun02 strongly decreases the excitability of rat MSN primary cultures expressing β-galactosidase upon D1 dopamine receptor stimulation; Daun02-inactivation method, selectively inactivate only those neurons activated by cocaine in an environment repeatedly paired with drug injections.

Daun 02;Daun-02

Antibody Drug Conjugates (ADC)

ADC Cytotoxin

ADC Cytotoxin

Cancer

——

290304-24-4

884.79

C41H44N2O20

>98% (HPLC)

10 mM in DMSO

O=C(OCC1=CC=C(O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)C([N+]([O-])=O)=C1)N[C@@H]3[C@H](O)[C@H](C)O[C@@H](OC4CC(O)(C(C)=O)CC5=C(O)C6=C(C(C7=C(OC)C=CC=C7C6=O)=O)C(O)=C45)C3

(1R,2R,6S,18R,20S)-3-nitro-4-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)benzyl (2S,3S,4S,6R)-6-(3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yloxy)-3-hydroxy-2-methyl-tetrahydro-2H

(-20℃)

With Ice Pack

≥ 2 years