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ZYN57939
CAS No. 1639357-93-9
ZYN57939 ( MTR-106 )
Catalog No. M23736 CAS No. 1639357-93-9
ZYN57939 is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases.?ZYN57939 showed inhibitory activity with IC50 of 0.855 μM against human HT- 29 cancer cell lines.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 234 | In Stock |
|
| 10MG | 334 | In Stock |
|
| 25MG | 534 | In Stock |
|
| 50MG | 763 | In Stock |
|
| 100MG | 1053 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameZYN57939
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NoteResearch use only, not for human use.
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Brief DescriptionZYN57939 is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases.?ZYN57939 showed inhibitory activity with IC50 of 0.855 μM against human HT- 29 cancer cell lines.?
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DescriptionZYN57939 is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases.?ZYN57939 showed inhibitory activity with IC50 of 0.855 μM against human HT- 29 cancer cell lines.?
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SynonymsMTR-106
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorRNA polymerase I
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Research Area——
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Indication——
Chemical Information
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CAS Number1639357-93-9
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Formula Weight524.6
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Molecular FormulaC29H28N6O2S
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Purity>98% (HPLC)
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SolubilityDMSO:Insoluble;Water:Insoluble
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SMILESO=C1C(C(NCC2=NC=C(N=C2)C)=O)=C(SC3=CC=CC=C34)N4C5=NC(C6C[C@@](CN(C)C7)([H])[C@@]7([H])C6)=CC=C15
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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HALOFUGINONE LACTATE
HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM.?Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activityhalofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of T(H)17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway.?HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity;?this inhibition is reversed by the addition of exogenous proline or EPRS.
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2'-Deoxyuridine
2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis.
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MM41
MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.
