
ZYN57939
CAS No. 1639357-93-9
ZYN57939( MTR-106 )
Catalog No. M23736 CAS No. 1639357-93-9
ZYN57939 is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases.?ZYN57939 showed inhibitory activity with IC50 of 0.855 μM against human HT- 29 cancer cell lines.?
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 234 | In Stock |
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10MG | 334 | In Stock |
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25MG | 534 | In Stock |
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50MG | 763 | In Stock |
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100MG | 1053 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameZYN57939
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NoteResearch use only, not for human use.
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Brief DescriptionZYN57939 is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases.?ZYN57939 showed inhibitory activity with IC50 of 0.855 μM against human HT- 29 cancer cell lines.?
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DescriptionZYN57939 is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases.?ZYN57939 showed inhibitory activity with IC50 of 0.855 μM against human HT- 29 cancer cell lines.?
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In VitroCell Viability Assay Cell Line:HR-deficient and PARPi-resistant cancer cells Concentration:0-100 μM Incubation Time:7 days Result:Inhibited the viability of HR-deficient cells and PARPi-resistant cells in a dose-dependent nanner.Cell Cycle Analysis Cell Line:Capan-1 cells Concentration:0.1, 0.3, and 1 μM Incubation Time:24 hours Result:Increased in cells in G2/M, accompanied by a reduction in cell numbers in G1.Western Blot Analysis Cell Line:Capan-1 cells Concentration:1, 5, and 10 μM Incubation Time:24 hours Result:Increased the cleaved caspases 3, 7, and 9 and cleaved PARP in a dose-dependent manner.
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In VivoAnimal Model:BRCA-deficient and PARPi-resistant xenografts in nude mice Dosage:10, 20, and 30 mg/kg Administration:oral administration; twice a week, for 29 days Result:Inhibited tumor growth in a dose-dependent manner.
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SynonymsMTR-106
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorRNA polymerase I
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Research Area——
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Indication——
Chemical Information
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CAS Number1639357-93-9
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Formula Weight524.62
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Molecular FormulaC29H28N6O2S
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Purity>98% (HPLC)
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SolubilityDMSO:Insoluble;Water:Insoluble
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SMILESO=C1C(C(NCC2=NC=C(N=C2)C)=O)=C(SC3=CC=CC=C34)N4C5=NC(C6C[C@@](CN(C)C7)([H])[C@@]7([H])C6)=CC=C15
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers[J]. Investigational New Drugs, 2021:1-9.
molnova catalog



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