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NCGC00029283

CAS No. 714240-31-0

NCGC00029283( —— )

Catalog No. M35229 CAS No. 714240-31-0

NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NCGC00029283
  • Note
    Research use only, not for human use.
  • Brief Description
    NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM.
  • Description
    NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively.
  • In Vitro
    NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells.Cell Proliferation Assay Cell Line:U2-OS cells Concentration:1 μM, 10 μM, 100 μM Incubation Time:24 h, 48 h, 72 h Result:Showed a reduction in U2-OS cell proliferation.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    714240-31-0
  • Formula Weight
    337.3
  • Molecular Formula
    C18H12FN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 6.94 mg/mL (20.58 mM; Ultrasonic (<60°C)
  • SMILES
    COc1ccc2[nH]c(=O)c(cc2c1)-c1noc(n1)-c1ccc(F)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Joshua A Sommers, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN). PLoS One. 2019 Jan 9;14(1):e0210525.?
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