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ZLN-024
CAS No. 723249-01-2
ZLN-024 ( ZLN024 )
Catalog No. M15768 CAS No. 723249-01-2
A novel AMPK allosteric activator that has no effect on mitochondrial function or the ADP/ATP ratio; directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 302 | Get Quote |
|
| 10MG | 447 | Get Quote |
|
| 25MG | 714 | Get Quote |
|
| 50MG | 1017 | Get Quote |
|
| 100MG | 1368 | Get Quote |
|
| 500MG | 2673 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameZLN-024
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NoteResearch use only, not for human use.
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Brief DescriptionA novel AMPK allosteric activator that has no effect on mitochondrial function or the ADP/ATP ratio; directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively.
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DescriptionA novel AMPK allosteric activator that has no effect on mitochondrial function or the ADP/ATP ratio; directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively; also directly activate recombinant AMPK α1β2γ1 (EC50=1.1 μuM) and AMPK α2β2γ1 (EC50=0.13 uM); activates AMPK in L6 myotubes and stimulates glucose uptake and fatty acid oxidation; improves glucose tolerance, liver tissue weight, triacylglycerol and decreases the total cholesterol content in db/db mice (15 mg/kg/day).Diabetes Preclinical
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SynonymsZLN024
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PathwayMembrane Transporter/Ion Channel
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TargetAMPK
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RecptorAMPK
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Research AreaMetabolic Disease
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IndicationDiabetes
Chemical Information
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CAS Number723249-01-2
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Formula Weight325.22
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Molecular FormulaC13H13BrN2OS
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=CC(=C(C=C1)OCCSC2=NC=CC=N2)Br
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Chemical NamePyrimidine, 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang LN, et al. PLoS One. 2013 Aug 20;8(8):e72092.
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ZLN-024
A novel AMPK allosteric activator that has no effect on mitochondrial function or the ADP/ATP ratio; directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively.
