PF-06409577 ( PF 06409577;PF06409577;PF 6409577 )

Catalog No. M11999 CAS No. 1467057-23-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-06409577
Note

Research use only, not for human use.
Brief Description

PF-06409577(PF06409577, PF 6409577)is a potent, selective AMPK β1-containing isoforms activator with TR-FRET EC50 of 7.0 and 6.8 nM for α1β1γ1 and α2β1γ1, respectively.
Description

PF-06409577(PF06409577, PF 6409577)is a potent, selective AMPK β1-containing isoforms activator with TR-FRET EC50 of 7.0 and 6.8 nM for α1β1γ1 and α2β1γ1, respectively; displays no activity for α1β2γ1/α2β2γ1/α2β2γ3 with EC50 >40 uM; elevates the phosphorylation of AMPK in the kidney, without impacting blood glucose levels, and reduces the progression of proteinuria in rat model of diabetic nephropathy. Diabetes Phase 1 Discontinued
Synonyms

PF 06409577;PF06409577;PF 6409577
Pathway

Membrane Transporter/Ion Channel
Target

AMPK
Recptor

AMPKα1β1γ1
Research Area

Metabolic Disease
Indication

Diabetes

CAS Number

1467057-23-3
Formula Weight

341.79
Molecular Formula

C19H16ClNO3
Purity

>98% (HPLC)
Solubility

DMSO: 34.2 mg/mL (100 mM); Ethanol: 6.8 mg/mL (20 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(C1=CNC2=C1C=C(C3=CC=C(C4(O)CCC4)C=C3)C(Cl)=C2)O
Chemical Name

6-Chloro-5-[4-(1- hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid

1. Cameron KO, et al. J Med Chem. 2016 Sep 8;59(17):8068-81.
2. Salatto CT, et al. J Pharmacol Exp Ther. 2017 May;361(2):303-311.

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