MK-3903 ( MK3903 )

Catalog No. M10828 CAS No. 1219737-12-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MK-3903
Note

Research use only, not for human use.
Brief Description

MK-3903 is a potent and selective, direct and oral AMPK activator with EC50 of 9 nM.
Description

MK-3903 is a potent and selective, direct and oral AMPK activator with EC50 of 9 nM; activates 10 of the 12 phosphorylated AMPK (pAMPK) complexes with EC50s of 8-40 nM, improves lipid metabolism and insulin sensitization in mice.
Synonyms

MK3903
Pathway

Membrane Transporter/Ion Channel
Target

AMPK
Recptor

AMPK
Research Area

——
Indication

——

CAS Number

1219737-12-8
Formula Weight

454.91
Molecular Formula

C27H19ClN2O3
Purity

>98% (HPLC)
Solubility

DMSO: 70 mg/mL; Water: Insoluble; Ethanol: Insoluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

CC1=C(C=C(C=C1)OC2=NC3=C(N2)C=C(C(=C3)C4=CC=C(C=C4)C5=CC=CC=C5)Cl)C(=O)O
Chemical Name

5-[(5-[1,1'-Biphenyl]-4-yl-6-chloro-1H-benzimidazol-2-yl)oxy]-2-methylbenzoic acid

1. Lan P, et al. J Med Chem. 2017 Nov 9;60(21):9040-9052.

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