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Z-360
CAS No. 209219-38-5
Z-360( Nastorazepide )
Catalog No. M13278 CAS No. 209219-38-5
A novel potent, orally active CCK-2/gastrin receptor antagonist with Ki of 0.47 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | Get Quote |
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| 10MG | 170 | Get Quote |
|
| 25MG | 327 | Get Quote |
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| 50MG | 498 | Get Quote |
|
| 100MG | 718 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameZ-360
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent, orally active CCK-2/gastrin receptor antagonist with Ki of 0.47 nM.
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DescriptionA novel potent, orally active CCK-2/gastrin receptor antagonist with Ki of 0.47 nM; significantly reduces gastrin-induced PKB/Akt phosphorylation in human CCK-2 receptor-expressing cells; significantly inhibits the growth of MiaPaCa2, also suppresses pancreatic tumor growth and prolong survival in a pancreatic carcinoma xenograft model combined with gemcitabine; prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 β production in a cancer-induced pain model in mice.Pancreatic Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsNastorazepide
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PathwayGPCR/G Protein
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TargetCholecystokinin Receptor
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RecptorCholecystokinin Receptor
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Research AreaCancer
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IndicationPancreatic Cancer
Chemical Information
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CAS Number209219-38-5
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Formula Weight520.6199
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Molecular FormulaC29H36N4O5
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 32 mg/mL
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SMILESO=C(O)C1=CC=CC(NC(N[C@@H]2CN(C3CCCCC3)C4=CC=CC=C4N(CC(C(C)(C)C)=O)C2=O)=O)=C1
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Chemical NameBenzoic acid, 3-[[[[(3R)-5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-2,3,4,5-tetrahydro-2-oxo-1H-1,5-benzodiazepin-3-yl]amino]carbonyl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kawasaki D, et al. Cancer Chemother Pharmacol. 2008 Apr;61(5):883-92.
2. Meyer T, et al. Eur J Cancer. 2010 Feb;46(3):526-33.
3. Orikawa Y, et al. Mol Pain. 2010 Oct 28;6:72.
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