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PF-04756956
CAS No. 1228934-52-8
PF-04756956( PF04756956 | PF 04756956 )
Catalog No. M10894 CAS No. 1228934-52-8
A potent, selective CCK1 receptor agonist with EC50 of 0.47 nM; elicits no biological response at the CCK2 receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePF-04756956
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective CCK1 receptor agonist with EC50 of 0.47 nM; elicits no biological response at the CCK2 receptors.
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DescriptionA potent, selective CCK1 receptor agonist with EC50 of 0.47 nM; elicits no biological response at the CCK2 receptors; demonstrates robust weight loss in a diet-induced obese rat model with very low systemic exposure.
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In Vitro——
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In Vivo——
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SynonymsPF04756956 | PF 04756956
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PathwayGPCR/G Protein
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TargetCholecystokinin Receptor
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RecptorCholecystokinin Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1228934-52-8
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Formula Weight649.799
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Molecular FormulaC40H39N7O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(4S)-4-((1H-indazol-3-yl)methyl)-6-(2-((R)-2-(3,5-dimethylbenzyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-5(6H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Desai AJ, et al. J Med Chem. 2015 Dec 24;58(24):9562-77.
2. Cameron KO, et al. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2943-7.
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