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YUM70

CAS No. 423145-35-1

YUM70( —— )

Catalog No. M24387 CAS No. 423145-35-1

YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein).?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    YUM70
  • Note
    Research use only, not for human use.
  • Brief Description
    YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein).?
  • Description
    YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein).?It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.?
  • In Vitro
    Western Blot Analysis Cell Line:MIA PaCa-2, PANC-1 cells Concentration:0.1, 1, 2.5, 5, 10 μM Incubation Time:2, 4, 8, 24, 48 hours Result:Increased the protein levels of FAM129A, DDIT3, CHAC-1, DDIT4, UPP1, and GRP78 in a dose- and time-dependent manner.
  • In Vivo
    Animal Model:8-week old female NCr nude mice were injected with MIA PaCa-2 cells Dosage:30 mg/kg Administration:I.p. 5 days a week for 7 weeks Result:Observed a significant tumor growth delay with no significant change in body weight during the course of treatment.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    GRP78
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    423145-35-1
  • Formula Weight
    398.84
  • Molecular Formula
    C21H19ClN2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL?(250.73 mM;?Need ultrasonic)
  • SMILES
    O=C(CCC)NC(C1=CC=C2C(OCO2)=C1)C(C=C(Cl)C3=C4N=CC=C3)=C4O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Samanta S, et, al. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2;canres.1540.2020.
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