Cart
sales@molnova.com
YM-201636
CAS No. 371942-69-7
YM-201636( YM 201636 | YM201636 )
Catalog No. M14284 CAS No. 371942-69-7
YM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibits type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 52 | In Stock |
|
| 5MG | 87 | In Stock |
|
| 10MG | 165 | In Stock |
|
| 25MG | 340 | In Stock |
|
| 50MG | 533 | In Stock |
|
| 100MG | 761 | In Stock |
|
| 500MG | 1557 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameYM-201636
-
NoteResearch use only, not for human use.
-
Brief DescriptionYM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibits type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM).
-
DescriptionYM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibits type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM); shows insensitivity against yeast orthologue of PIKfyve, Fab1; significantly decreases the production of PtdIns(3,5)P2 by 80% in serum-starved NIH3T3 cells with no effect on serum-stimulated PKB Ser 473 phosphorylation at 0.8 uM; inhibits basal and insulin-activated 2-deoxyglucose uptake withIC50 of 54 nM; significantly reduces retroviruses budding from cells; blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells.
-
In Vitro——
-
In Vivo——
-
SynonymsYM 201636 | YM201636
-
PathwayPI3K/Akt/mTOR signaling
-
TargetPIKfyve
-
Recptorp110α|PIKfyve
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number371942-69-7
-
Formula Weight467.4793
-
Molecular FormulaC25H21N7O3
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 47 mg/mL
-
SMILESO=C(C1=CC=C(N)N=C1)NC2=CC=CC(C3=NC(N4CCOCC4)=C(OC5=NC=CC=C56)C6=N3)=C2
-
Chemical Name3-Pyridinecarboxamide, 6-amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Jefferies HB, et al. EMBO Rep. 2008 Feb;9(2):164-70.
2. Osborne SL, et al. J Biol Chem. 2008 Feb 1;283(5):2804-13.
3. Ikonomov OC, et al. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70.
4. Kerr MC, et al. EMBO J. 2010 Apr 21;29(8):1331-47.
molnova catalog
related products
-
AS2677131
AS2677131(AS 2677131, AS-2677131) is a novel potent, oral PIKfyve inhibitor.
-
YM-201636
YM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibits type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM).
-
AS2795440
A novel potent, selective, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β.
