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AS2677131
CAS No. 2171502-44-4
AS2677131( AS 2677131 | AS-2677131 )
Catalog No. M13472 CAS No. 2171502-44-4
AS2677131(AS 2677131, AS-2677131) is a novel potent, oral PIKfyve inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAS2677131
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NoteResearch use only, not for human use.
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Brief DescriptionAS2677131(AS 2677131, AS-2677131) is a novel potent, oral PIKfyve inhibitor.
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DescriptionAS2677131(AS 2677131, AS-2677131) is a novel potent, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=4 nM); inhibits the production of IL-12p40, IL-6 and IL-1β but not TNFα in activated macrophages or dendritic cells, and expression of IgM-induced MHC class II on B cells; reduces Akt phosphorylation in IFNγ/LPS-stimulated RAW264.7 cells, greatly increases cell size with many small vesicles in the cytoplasm.
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In Vitro——
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In Vivo——
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SynonymsAS 2677131 | AS-2677131
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PathwayPI3K/Akt/mTOR signaling
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TargetPIKfyve
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RecptorPIKfyve
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Research Area——
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Indication——
Chemical Information
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CAS Number2171502-44-4
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Formula Weight470.577
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Molecular FormulaC27H30N6O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Namerel-N-{6'-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-3,3'-bipyridin-5-yl}-3-ethyl-2-methyl-1H-pyrrolo[3,2-b]pyridine-5-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Terajima M, et al. Eur J Pharmacol. 2016 Jun 5;780:93-105.
molnova catalog
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AS2677131
AS2677131(AS 2677131, AS-2677131) is a novel potent, oral PIKfyve inhibitor.
