AMP-PCP( —— )

Catalog No. M21917 CAS No. 3469-78-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

AMP-PCP
Note

Research use only, not for human use.
Brief Description

AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90.
Description

AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90.AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP.
In Vitro

AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP.
In Vivo

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Synonyms

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Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

HSP
Recptor

HSP90
Research Area

——
Indication

——

CAS Number

3469-78-1
Formula Weight

505.21
Molecular Formula

C??H??N?O??P?
Purity

>98% (HPLC)
Solubility

——
SMILES

O[C@H]1[C@@H](O[C@H](COP(OP(CP(O)(O)=O)(O)=O)(O)=O)[C@H]1O)N2C3=C(C(N)=NC=N3)N=C2
Chemical Name

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1. Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542.

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