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YLC2-155

CAS No. 1354742-60-1

YLC2-155( YLC 2-155 | YLC2155 )

Catalog No. M11447 CAS No. 1354742-60-1

YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    YLC2-155
  • Note
    Research use only, not for human use.
  • Brief Description
    YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT.
  • Description
    YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT; binds at the RNase H (RNH)-active site in multiple conformations; demonstrates inhibition of fully infectious HIV-1 (strain NL4-3) with EC50 of 6.7 uM in cell-based assays.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    YLC 2-155 | YLC2155
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1354742-60-1
  • Formula Weight
    243.22
  • Molecular Formula
    C13H9NO4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    7-(furan-2-yl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kirby KA, et al. Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01351-17. 2. Kirby KA, et al. Antimicrob Agents Chemother. 2012 Apr;56(4):2048-61.
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