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YKL-1-116
CAS No. 1957202-71-9
YKL-1-116 ( YKL-1-116; YKL 1 116; YKL1116 )
Catalog No. M13065 CAS No. 1957202-71-9
YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs; synergizes with 5-FU or nutlin-3 to kill HCT116 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1413 | Get Quote |
|
| 50MG | 2862 | Get Quote |
|
| 100MG | 3870 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameYKL-1-116
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NoteResearch use only, not for human use.
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Brief DescriptionYKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs; synergizes with 5-FU or nutlin-3 to kill HCT116 cells.
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DescriptionYKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs; synergizes with 5-FU or nutlin-3 to kill HCT116 cells, produces dose-dependent increases in PARP cleavage; is more potent than THZ1 towards both Cdk7WT and Cdk7as (analog-sensitive mutant).
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SynonymsYKL-1-116; YKL 1 116; YKL1116
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number1957202-71-9
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Formula Weight606.73
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Molecular FormulaC34H38N8O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N(C1)C(C)(C)C2=C1C(NC3=CC=CC(NC(C4=CC=C(NC(C=C)=O)C=C4)=O)=C3)=NN2)N[C@@H](C5=CC=CC=C5)CN(C)C
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Chemical Name(S)-3-((3-(4-acrylamidobenzamido)phenyl)amino)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Benzo[b]thiophene-2-...
Benzo[b]thiophene-2-sulfonamide, N-[3-(aminomethyl)phenyl]-5-chloro-3-methyl- directly inhibits InhA and does not require activation by the catalase peroxidase KatG.
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Trilaciclib hydrochl...
Trilaciclib hydrochloride is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).Incubation with Trilaciclib hydrochloride (G1T28) for 24 hours can induce a strong G1 cell cycle arrest (time=0). Cells have re-entered the cell cycle and demonstrate cell-cycle kinetics similar to untreated control cells By 16 hours after Trilaciclib hydrochloride washout.
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1NM-PP1
1NM-PP1(PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors(IC50=28 uM vSrc; 4.2 nM v-Src-as1 I338G).
