YKL-1-116 ( YKL-1-116; YKL 1 116; YKL1116 )

Catalog No. M13065 CAS No. 1957202-71-9

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HNMR

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Product Name

YKL-1-116
Note

Research use only, not for human use.
Brief Description

YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs; synergizes with 5-FU or nutlin-3 to kill HCT116 cells.
Description

YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs; synergizes with 5-FU or nutlin-3 to kill HCT116 cells, produces dose-dependent increases in PARP cleavage; is more potent than THZ1 towards both Cdk7WT and Cdk7as (analog-sensitive mutant).
Synonyms

YKL-1-116; YKL 1 116; YKL1116
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

CAS Number

1957202-71-9
Formula Weight

606.73
Molecular Formula

C34H38N8O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N(C1)C(C)(C)C2=C1C(NC3=CC=CC(NC(C4=CC=C(NC(C=C)=O)C=C4)=O)=C3)=NN2)N[C@@H](C5=CC=CC=C5)CN(C)C
Chemical Name

(S)-3-((3-(4-acrylamidobenzamido)phenyl)amino)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide

1. Kalan S, et al. Cell Rep. 2017 Oct 10;21(2):467-481.

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