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Y08060
CAS No. 2222565-19-5
Y08060 ( Y 08060 )
Catalog No. M13549 CAS No. 2222565-19-5
Y08060 is a potent and selective BET inhibitor with Kd of 306 nM for BRD4 BD1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameY08060
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NoteResearch use only, not for human use.
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Brief DescriptionY08060 is a potent and selective BET inhibitor with Kd of 306 nM for BRD4 BD1.
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DescriptionY08060 is a potent and selective BET inhibitor with Kd of 306 nM for BRD4 BD1, displays excellent selectivity for BET subfamily over other non-BET family with the exception of moderate inhibition of CBP/EP300; esuppresses cell growth, colony formation, and expression of androgen receptor (AR), AR regulated genes, and MYC in prostate cancer cell lines. such as C4-2B, LNCaP, and 22Rv1; demonstrates good PK profile with high oral bioavailability (61.54%).
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SynonymsY 08060
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBromodomain
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Research Area——
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Indication——
Chemical Information
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CAS Number2222565-19-5
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Formula Weight471.32
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Molecular FormulaC18H19BrN2O6S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name5-bromo-2-methoxy-N-(6-methoxy-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)benzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xiang Q, et al. ACS Med Chem Lett. 2018 Feb 13;9(3):262-267.
molnova catalog
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