Y08060 ( Y 08060 )

Catalog No. M13549 CAS No. 2222565-19-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Y08060
Note

Research use only, not for human use.
Brief Description

Y08060 is a potent and selective BET inhibitor with Kd of 306 nM for BRD4 BD1.
Description

Y08060 is a potent and selective BET inhibitor with Kd of 306 nM for BRD4 BD1, displays excellent selectivity for BET subfamily over other non-BET family with the exception of moderate inhibition of CBP/EP300; esuppresses cell growth, colony formation, and expression of androgen receptor (AR), AR regulated genes, and MYC in prostate cancer cell lines. such as C4-2B, LNCaP, and 22Rv1; demonstrates good PK profile with high oral bioavailability (61.54%).
Synonyms

Y 08060
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

2222565-19-5
Formula Weight

471.32
Molecular Formula

C18H19BrN2O6S
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

5-bromo-2-methoxy-N-(6-methoxy-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)benzenesulfonamide

1. Xiang Q, et al. ACS Med Chem Lett. 2018 Feb 13;9(3):262-267.

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